An updated roadmap for MERS-CoV research and product development: focus on diagnostics
Identifieur interne : 000025 ( France/Analysis ); précédent : 000024; suivant : 000026An updated roadmap for MERS-CoV research and product development: focus on diagnostics
Auteurs : Cassandra Kelly-Cirino [Suisse] ; Laura T. Mazzola [Suisse] ; Arlene Chua [Suisse] ; Christopher J. Oxenford [France] ; Maria D. Van Kerkhove [Suisse]Source :
- BMJ Global Health [ 2059-7908 ] ; 2019.
Abstract
Diagnostics play a central role in the early detection and control of outbreaks and can enable a more nuanced understanding of the disease kinetics and risk factors for the Middle East respiratory syndrome-coronavirus (MERS-CoV), one of the high-priority pathogens identified by the WHO. In this review we identified sources for molecular and serological diagnostic tests used in MERS-CoV detection, case management and outbreak investigations, as well as surveillance for humans and animals (camels), and summarised the performance of currently available tests, diagnostic needs, and associated challenges for diagnostic test development and implementation. A more detailed understanding of the kinetics of infection of MERS-CoV is needed in order to optimise the use of existing assays. Notably, MERS-CoV point-of-care tests are needed in order to optimise supportive care and to minimise transmission risk. However, for new test development, sourcing clinical material continues to be a major challenge to achieving assay validation. Harmonisation and standardisation of laboratory methods are essential for surveillance and for a rapid and effective international response to emerging diseases. Routine external quality assessment, along with well-characterised and up-to-date proficiency panels, would provide insight into MERS-CoV diagnostic performance worldwide. A defined set of Target Product Profiles for diagnostic technologies will be developed by WHO to address these gaps in MERS-CoV outbreak management.
Url:
DOI: 10.1136/bmjgh-2018-001105
PubMed: 30815285
PubMed Central: 6361340
Affiliations:
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PMC:6361340Le document en format XML
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Mazzola</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Emerging Threats Programme</institution>,<institution>FIND</institution>,<addr-line content-type="city">Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chua, Arlene" sort="Chua, Arlene" uniqKey="Chua A" first="Arlene" last="Chua">Arlene Chua</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Department of Information, Evidence and Research</institution>,<institution>WHO</institution>,<addr-line content-type="city">Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Medecins Sans Frontières</institution>,<addr-line content-type="city">Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oxenford, Christopher J" sort="Oxenford, Christopher J" uniqKey="Oxenford C" first="Christopher J" last="Oxenford">Christopher J. Oxenford</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="department">Health Emergencies Programme</institution>,<institution>WHO</institution>,<addr-line content-type="city">Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D" last="Van Kerkhove">Maria D. Van Kerkhove</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="department">Health Emergencies Programme</institution>,<institution>WHO</institution>,<addr-line content-type="city">Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMJ Global Health</title><idno type="eISSN">2059-7908</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Diagnostics play a central role in the early detection and control of outbreaks and can enable a more nuanced understanding of the disease kinetics and risk factors for the Middle East respiratory syndrome-coronavirus (MERS-CoV), one of the high-priority pathogens identified by the WHO. In this review we identified sources for molecular and serological diagnostic tests used in MERS-CoV detection, case management and outbreak investigations, as well as surveillance for humans and animals (camels), and summarised the performance of currently available tests, diagnostic needs, and associated challenges for diagnostic test development and implementation. A more detailed understanding of the kinetics of infection of MERS-CoV is needed in order to optimise the use of existing assays. Notably, MERS-CoV point-of-care tests are needed in order to optimise supportive care and to minimise transmission risk. However, for new test development, sourcing clinical material continues to be a major challenge to achieving assay validation. Harmonisation and standardisation of laboratory methods are essential for surveillance and for a rapid and effective international response to emerging diseases. Routine external quality assessment, along with well-characterised and up-to-date proficiency panels, would provide insight into MERS-CoV diagnostic performance worldwide. A defined set of Target Product Profiles for diagnostic technologies will be developed by WHO to address these gaps in MERS-CoV outbreak management.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Aguanno, R" uniqKey="Aguanno R">R Aguanno</name></author><author><name sortKey="Elidrissi, A" uniqKey="Elidrissi A">A ElIdrissi</name></author><author><name sortKey="Elkholy, Aa" uniqKey="Elkholy A">AA Elkholy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author><author><name 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Olofsson</name></author><author><name sortKey="Brittain Long, R" uniqKey="Brittain Long R">R Brittain-Long</name></author><author><name sortKey="Andersson, Lm" uniqKey="Andersson L">LM Andersson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name></author><author><name sortKey="Spreeuwenberg, P" uniqKey="Spreeuwenberg P">P Spreeuwenberg</name></author><author><name sortKey="Lustig, R" uniqKey="Lustig R">R Lustig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goktas, S" uniqKey="Goktas S">S Goktas</name></author><author><name sortKey="Sirin, Mc" uniqKey="Sirin M">MC Sirin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahony, J" uniqKey="Mahony J">J Mahony</name></author><author><name sortKey="Chong, S" uniqKey="Chong S">S Chong</name></author><author><name sortKey="Merante, F" uniqKey="Merante F">F Merante</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Suisse</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Kelly Cirino, Cassandra" sort="Kelly Cirino, Cassandra" uniqKey="Kelly Cirino C" first="Cassandra" last="Kelly-Cirino">Cassandra Kelly-Cirino</name></noRegion><name sortKey="Chua, Arlene" sort="Chua, Arlene" uniqKey="Chua A" first="Arlene" last="Chua">Arlene Chua</name><name sortKey="Chua, Arlene" sort="Chua, Arlene" uniqKey="Chua A" first="Arlene" last="Chua">Arlene Chua</name><name sortKey="Mazzola, Laura T" sort="Mazzola, Laura T" uniqKey="Mazzola L" first="Laura T" last="Mazzola">Laura T. Mazzola</name><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D" last="Van Kerkhove">Maria D. Van Kerkhove</name></country><country name="France"><noRegion><name sortKey="Oxenford, Christopher J" sort="Oxenford, Christopher J" uniqKey="Oxenford C" first="Christopher J" last="Oxenford">Christopher J. Oxenford</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000025 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000025 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= France
|étape= Analysis
|type= RBID
|clé= PMC:6361340
|texte= An updated roadmap for MERS-CoV research and product development: focus on diagnostics
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:30815285" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |